Zanocin user's manual

We ask you to pay your attention that before buying the drug Zanocin, you should carefully read the instructions for use, the methods of application and dosage, as well as other useful information on Zanocin. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews of patients who have already used this medication.

Zanotsin - Composition and form of release

Zanocin 100. Each film-coated tablet contains: ofloxacin 100 mg.

Zanocin 200. Each film-coated tablet contains: ofloxacin 200 mg.

Microbiology

Zanotsin is a potent, bactericidal antibacterial agent. It is believed that the bactericidal action of Zanocin, as well as other fluorinated quinolones, is based on its ability to inhibit the bacterial DNA enzyme gyrase. It is also believed that it has a strong and rapid effect due to an additional mode of action: it is capable of damaging the cell membrane of the bacterium, which leads to a loss of cellular content. The dual mode of action of ofloxacin should have advantages, since bacteria have to overcome a double obstacle.

Zanocin is a broad-spectrum antibacterial agent that is effective against the following types of bacteria:

Microorganism MPK90 (μg / ml)

Aerobic Gram-negative bacteria
Escherichia coli 0.097-1
Klebsiella spp. 0.25-1
Proteus spp. (Indolpositive and negative) 0.25
Enterobacter spp. 0.125-2.5
Morganella morganii 0.06-0.5
Providencia spp. 1.6-4
Citrobacter spp. 0.125-4
Acinetobacter spp. 0.5-2
Pseudomoonas aeruginosa 2-8
Ps. sepacia 0.5-1
H. influenzae 0.02-0.6
B. catarrhalis 0.02-0.06
N. gonorrhoeae 0.008-0.06
N. meningitidis 0.015-0.03
Enteropathogenic and non-enteropathogenic E.Coli 0.097-1
Salmonella spp. 0.03-0.097
Salmonella typhi 0.03-0.125
Shigella spp. 0.03-0.05
V. cholerae 0.002-0.015
Serratia spp. 0.5-2.5
Y. enterocolitica 0.02-0.1
Campylobacter jejuni 0.25-0.5
Bacteroides spp. 2-4
Fusobacterium spp. 1-4
Gardnerella vaginalis 1-2
Aerobic Gram-positive bacteria
Staph. aureus (including beta-lactamase-forming) 0.12-0.5
Staph. epidermidis 0.12-0.5
Strep. pyogenes 0.5-1
Strep. pneumoniae 1-4
Strep. faecalis 1-8
Strep. viridans 1-4
Other Strep. spp. 1-8
Other
Chlamydia trachomatis 0.5
Ureaplasma urealyticum 1.6-8
Mycoplasma spp. 0.12-2
Legionella spp. 0.12-1
Brucella spp. 0.05-0.1

It is impossible to consider Zanocin therapeutically effective against anaerobes. Although the anti-aerobic activity is higher than that of other fluoroquinolones, the drug is active only against certain strains, so if it is suspected of anaerobic microflora, it should be combined with metronidazole or clindamycin.

Zanocin is not active against T. pallidum, viruses, protozoa and fungi.

Zanocin - Pharmacokinetics

Zanocin is rapidly and significantly absorbed from the gastrointestinal tract and has a linear blood level dependence on the dose at dose concentrations of 200-600 mg. Peak plasma concentrations are approximately 2 and 5 μg / ml after a single dose of 200 and 400 and 800, respectively. Food does not reduce the absorption of ofloxacin, but it may delay the suction rate a little. Ofloxacin is widely distributed over body tissues and fluids, there are data on the volume of distribution from 1.0 to 2.5 l / kg.

Zanotsin is mainly secreted with urine unchanged. The concentration in the urine after 4 hours after a single oral dose of 100 mg was 155 μg / ml and exceeded 10 μg / ml even after 22-24 hours. The concentration of ofloxacin in urine remained well above the MIc90 values ​​for most bacterial species for more than 4.5 days after the last of 14 doses of 300 mg ofloxacin taken twice daily. A small part of ofloxacin excreted with feces unchanged. The half-life of Zanotsin is about 6 hours or more. Since ofloxacin is excreted primarily through the kidneys, its pharmacokinetics undergoes significant changes in patients with impaired renal function. In elderly patients (aged 65-85 years) with an average creatinine release of 50 ml / min. the half-life can increase to 13.3 hours.

Toxicology

Toxicological studies of Zanocin have shown that it does not have a teratogenic effect and is not toxic to the embryo, except for data on damage to embryonic cartilage and underdeveloped Bigles puppies. The importance of this data in the case of humans is not defined.

Zanocin - Indications for use

• Infections of the urinary tract, both upper and lower, acute or chronic, with or without complications, including infections caused by pseudomonas and other nosocomial organisms that are resistant to the action of multiple drugs. This includes cystitis, acute and chronic hydronephritis, epididymitis, prostatitis and chronic complicated or recurrent urinary tract infection.

• Infections of the respiratory tract, both upper and lower, acute or chronic, with or without complications, including infections caused by Gram-positive cocci to the betalactamase producing bacteria like H. Influenzae.

• Venereal diseases of the urethra, neck, rectum and pharynx caused by persistent penicillin gonococci, chlamydia and other organisms that cause non-gonococcal urethritis.

• Inflammation of the pelvic organs, including inflammation due to mixed infections or chlamydia.

• Infections of the ear, throat, nose, including tonsillitis, otitis media and sinusitis caused by gram-positive or gram-negative bacteria.

• Gastrointestinal infections, including bacterial dysentery.

• Infections of the skin and soft tissues, including impetigo , cellulite and erysipelas caused by Staph, aureus (strains sensitive to penicillin or resistant to penicillin and / or methicillin), Pseudomonas and other gram-positive and gram-negative bacteria.

• Postpartum and gynecological infections, including adnexitis , intrauterine infections or parametritis . If necessary, give Zanotsin a nursing mother, she should temporarily give the child artificial nutrition and do not throw away her milk during Zanotsin's therapy and 3-4 days after the treatment until the resumption of feeding.

• Various conditions include the following: infections of surgical wounds, cholecystitis, cholangitis, blepharitis , barley , dacryocystitis, keratitis.

• Infections of the central nervous system (there is a limitation of the data).

• Septicemia, when oral therapy is possible.

Endocarditis .

• Prevention after surgery.

• Prevention of infection in patients with weak immunity or neutropenia .

• Abdominal infections.

Osteomyelitis .

To ofloxacin (Zanotsin), 94% of strains of genital infections are sensitive, (except protozoa and anaerobes), 93% of strains are causative agents of urological infections.

Permissible deviations

Clinical trials of ofloxacin among 15,962 patients show that the incidence of adverse adverse reactions to the drug was 4.27%. Symptoms were generally weak and mainly associated with the gastrointestinal tract, nervous system or allergic reactions.

Major side effects include the following:

Action - frequency,%.

Gastrointestinal 2.64%

Nervous system 0.89%

Allergy 0.53%

Other 0.21%

These include:

Gastrointestinal disorders - nausea, vomiting, diarrhea, gastric discomfort, anorexia .

Neurological - dizziness , headaches, insomnia, photophobia and weakness.

Allergic - rash, fever, itching and dropsy.

Rarely there were increases in renal function tests (SGOT, SPGT).

Some patients complained of weakness, thirst, nervousness, tachycardia, trembling, stomatitis, cheilitis, burning sensation and photophobia.

There was no clear connection between the frequency / severity of these actions and the dose of Zanocin.

Zanotsin - Precautions

Zanocin, like other fluorinated quinolones, should be used with caution in patients with central nervous system disorders, such as epilepsy and acute cerebral arteriosclerosis. Patients should take a copious amount of water to avoid crystalluria. It is necessary to reduce the dose of the drug in the case of patients with renal insufficiency and in the case of the elderly in order to compensate for the delayed release.

In toxicological studies among animals, ofloxacin, like other fluorinated quinolones, caused arthropathy and cartilage toxicity in immature dogs. Therefore, its use by children, adolescents and pregnant women is not recommended.

Zanocin - Contraindications

Allergy to quinolones. Pregnancy and lactation. Children and teenagers.

Zanocin - Interaction with other drugs

Antacid agents may interfere with the absorption of ofloxacin, it is recommended to avoid joint administration with ofloxacin. Unlike other fluorenated quinolones, ofloxacin rarely leads to an increase in the level of theophylline in the blood. Therefore, it is the most reliable fluorinated quinolone in the case of respiratory tract infections, where theophylline may also be needed.

Zanocin - Dosage and Administration

For adults, the usual oral dose of Zanocin is: 400 mg in two equal divided doses (1 table 200 mg twice daily) for infections, respiratory tract, soft tissue skin, otolaryngological infections, surgical infections of bone infections, gynecological infections, complicated infections of the upper urinary tract, cholecystitis, cholangitis and gastrointestinal infections.

200 mg per day in single or two equal, divided doses in the case of uncomplicated lower urinary tract infections. Acute salpingitis: 400 mg x 2 r / day 10-14 days 99%.

Severe gynecological infections: 200 mg x 2 r / day iv 3 days then orally 15 days 98%. Ofloxacin 200 mg x 2 r / day for 10 days.

A single dose of 200 mg in the case of uncomplicated gonorrhea. Ofloxacin (Zanocin) is recommended by experts from the US Centers for Disease Control. Acute uncomplicated gonorrhea - 400 mg once. Chronic and torpid - 400 mg x 1 p / day - 4-5 days. In the presence of concomitant microflora (Chlamydia trachomatis, Ureaplasma urealyticum) - longer therapy (not less than 7 days) 300 mg x 2 r / day is needed.

The effectiveness of ofloxacin (Zanotsin) in chlamydia: 400 mg x 2p / day - 10 days. 99%. 88% of cefoxitin / doxycycline 300 mg x 2p / day - 7 days. 98% 90% of erythromycin. 300 mg x 2p / day - 7 days. 97% 88% doxycycline 200 mg x 2p / day - 7 days 83% 60% ciprofloxacin.

More potent doses up to 800 mg in two or three divided doses may be necessary in patients with acute infections presumably caused by streptococcal pathogens.

Patients with impaired renal function. The initial dose does not change. However, it is possible to give a maintenance dose of 200 or 100 ml per day for those with serum creatinine levels of 1.5 to 5 mg% and 100 mg every other day for those with a level greater than 5 mg%. Patients undergoing hemodialysis or peritoneal dialysis may need a dose of 100 mg every other day.

Food does not interfere with the bioavailability of the drug. It is not recommended to give antacids with Zanotsin. Passing course of treatment patients should not unduly expose themselves to the action of the sun. The treatment period may vary depending on the type and severity of the infection. However, the dose should be continued at least 2-3 days after the symptoms of the infection have disappeared.

In most cases, the treatment period should be 7-10 days. Uncomplicated urinary tract infections can be treated only for 3 days. It is not recommended to continue treatment with Zanotsin for more than 2 months.

Zanotsin - Overdose

Complete data on the overdose of ofloxacin is limited.

Symptoms: confusion, drowsiness, confusion, disorientation, dizziness, nausea, vomiting.

Treatment: there is no specific antidote. In case of an overdose, wash the stomach, prescribe adsorbents and sodium sulfate (if possible, during the first 30 minutes), use antacid preparations to protect the gastric mucosa. The patient is examined and, if necessary, hydrated. Organized diuresis accelerates the excretion of ofloxacin from the body. Hemodialysis or peritoneal dialysis is ineffective.

Analogues Zanotsin

Vero-Ofloxacin, Glaufos, Danzil , Geoflox, Zanotsin, Zoflox, Kirol, Menfloqs, Ornid, Oflin, Oflo, Oflox, Ofloxabol, Ofloxacin, Ofloxacin DS, Ofloxacin Protech, Ofloxacin-ICN, Ofloxacin-AKOS, Ofloxacin-Promed, Ofloxacin- FPO, Ofloksin, Ofloksin 200, Oflomak, Oflotsid, Oflotsid forte, Tarivid, Tariferid, Taricin, Unifloks, Urosin, Floksal

Storage conditions

Store in a dry, dark place at a temperature of up to 25 ° C.

We want to pay special attention to the fact that the description of the drug Zanocin is presented for informational purposes only! For more accurate and detailed information about the drug Zanocin, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!