Ospamox: instructions for use

Before buying the drug Ospamox, you should carefully read the instructions for use, methods of application and dosage, as well as other useful information about the drug Ospamox. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews of patients who have already used this medication.

Ospamoks - Form of release and composition

Tablets are dispersible, containing 500 mg of active substance, 12 pieces each in a blister, 1 blister in a carton.

Tablets are dispersible, containing 750 mg of active substance, 12 pieces each in a blister, 1 blister in a carton.

Tablets are dispersible, containing 1000 mg of active substance, 12 pieces each in a blister, 1 blister in a cardboard package.

1 tablet dispersible Ospamox DT 500 contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 500 mg;
Excipients, including aspartame.

1 tablet dispersible Ospamox DT 750 contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 750 mg;
Excipients, including aspartame.

1 tablet dispersible Ospamox DT 1000 contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 1000 mg;
Excipients, including aspartame.

Ospamox - Pharmacological action

Ospamox is a beta-lactam antibiotic of the penicillin series with a pronounced bactericidal effect. The active substance of the drug is amoxicillin, a semisynthetic drug of the aminopenicillin group. The drug shows antimicrobial activity against Gram-positive and Gram-negative aerobes, as well as some strains of anaerobic bacteria.

Like other unprotected antimicrobial agents of the penicillin series, amoxicillin is inactivated by the action of penicillinase and is ineffective in treating diseases caused by strains of microorganisms producing beta-lactamases.

The mechanism of action of the drug lies in its ability to disrupt the synthesis of the biopolymer peptidoglycan, which is the main component of the cell membrane of microorganisms. Blocking the synthesis of peptidoglycan occurs due to the influence of the molecule of amoxicillin on penicillin-binding proteins, which are the enzymes necessary for the final stage of the synthesis of peptidoglycan. Thus, the drug Ospamox promotes the destruction of the structure of the cell membrane during the reproduction of bacteria, which ultimately causes their death.

Due to the lack of peptidoglycan and penicillin-binding proteins in mammals, the drug does not have a specific toxic effect on the macroorganism.

Ospamox is a broad-spectrum antibiotic that exhibits bactericidal activity against the following bacteria:

Gram-positive aerobic bacteria: Staphylococcus spp., Including Staphylococcus aureus and Staphylococcus haemolyticus (other than strains producing beta-lactamase), Streptococcus spp. (including Streptococcus pneumoniae).

Gram-negative aerobic bacteria: Corynebacterium spp., Campilobacter spp., Haemophilus influenzae, Proteus mirabilis, Neisseria meningitidis, Actinomycetes spp., Bordetella pertussis, Pasteurella multocida, Spirillum minus, Klebsiella spp., Bacillus anthracis, Escherichia coli, Shigella spp., Listeria spp ., Erysipelothrix rhysiopathiae, Spirochaeta (Leptospira, Treponema, Borrelia) and Streptobacilli spp.

In addition, the preparation is active against some gram-negative anaerobic bacteria, including against strains of Peptostreptococcus spp., Peptococcus spp., Clostridium spp.

Strains Streptococcus viridans, Neisseria gonorrhoeae, Salmonella spp., Bacteroides melaninogenicus and Fusobacterium spp. have a non-permanent sensitivity to amoxicillin, therefore it is recommended to perform sensitivity tests before starting therapy with Ospamox.

After oral administration, the drug is rapidly absorbed in the small intestine, the absolute bioavailability of amoxicillin for oral administration is 75 to 90%, depending on the dose taken. When using the drug in doses from 250 mg to 750 mg, the bioavailability is proportional to the dose, when using higher doses of the drug, the bioavailability is somewhat reduced. The intake of food at the rate of absorption and bioavailability of the drug is not affected. The peak concentration of active substance in the blood plasma is achieved after 1-2 hours after oral administration of the drug. The degree of bond of amoxicillin with plasma proteins does not exceed 17%.

The drug creates high therapeutic concentrations in virtually all biological fluids and body tissues, in particular high concentrations of amoxicillin are noted in the lungs, bronchial secretions, middle ear fluid, bile and urine. The drug penetrates the hematoplacental barrier and creates high concentrations in the amniotic fluid and fetal tissues, in an insignificant amount penetrates into breast milk. Amoxicillin weakly penetrates the blood-brain barrier, but with meningitis, the concentration of amoxicillin in the cerebrospinal fluid can reach 20% of the dose.

Ospamox is partially metabolized with the formation of pharmacologically inactive penicillic acid. It is excreted in urine (about 60-80%) and bile, both in unchanged form, and in the form of a pharmacologically inactive metabolite. Half-life in patients with normal renal function is from 1 to 2 hours, in patients with renal insufficiency - from 5 to 20 hours.

Ospamox - Indications for use

The drug is used to treat acute and chronic infectious diseases caused by microorganisms sensitive to amoxicillin, including:

• Infectious diseases of the genitourinary system and gynecological infections: prostatitis , cystitis , urethritis, gonorrhea , septic abortion, adnexitis , endometritis , as well as acute and chronic pyelonephritis. The drug can also be used to treat asymptomatic bacteriuria during pregnancy.

• Infectious diseases of the respiratory system and ENT organs: acute and chronic bronchitis, bacterial pneumonia, lung abscess, acute otitis media, sinusitis, pharyngitis, laryngitis.

• Infectious diseases of the gastrointestinal tract: dysentery, typhoid fever , cholecystitis, salmonellosis . In addition, the drug is used in complex antihelikobakternoy therapy.

• The drug is also used to treat patients with infectious diseases of the skin and soft tissues, including secondarily infected dermatoses, erysipelas .

• Ospamox can be used as a prophylactic for surgical interventions in the oral cavity or upper respiratory tract.

In addition, after determining the pathogen, it is possible to use the drug as a monotherapy or in combination with other antimicrobial agents for the treatment of infective endocarditis and bacterial meningitis.

Ospamox - Dosage and administration

The drug is taken orally, the tablet is swallowed, washed down with water, if necessary, the tablet can be ground. It is also possible to take the drug in the form of a suspension, which is formed by dissolving the tablet in water.

Ospamox DT is taken regardless of food intake, it is recommended to take the drug at regular intervals. The duration of the course of treatment and the dose of the drug is determined by the attending physician individually.

Adults and adolescents over the age of 12 years with acute bacterial infections of different locations are usually prescribed 500-750 mg of the drug 2 times a day or 500 mg of the drug 3 times a day. In patients with severe forms of infectious diseases, the dose of the drug may be increased. The maximum daily dose of amoxicillin for adults is 3 g.

Adults and adolescents over the age of 12 years in the scheme of eradication Helicobacter pylori usually prescribed 1 g of the drug Ospamox DT 2 times a day.

Adults with acute uncomplicated gonorrhea are usually prescribed 3 g of Ospamox DT once-only in combination with 1 g of probenecid.

Adults with uncomplicated infectious diseases of the urinary system usually prescribed to take 3 g of the drug 2 times with an interval of 12 hours.

Adults and adolescents over the age of 12 years with chronic infectious diseases, as well as during relapses, usually prescribed 750-1000 mg of the drug 3 times a day.

Adults during surgical interventions for the prevention of endocarditis usually appoint 3 g of the drug 60 minutes before the beginning of the surgical procedure. If necessary, it is possible to prescribe the drug again in a dose of 3 g after 6 hours.

The duration of the course of treatment is usually from 5 to 7 days, but in the presence of streptococcal infections it is recommended to prolong the course of taking the drug not less than 10 days. The drug should be taken within 2-3 days after the disappearance of the clinical symptoms of the disease.

Patients suffering from renal insufficiency need a dose adjustment:

- Patients with a creatinine clearance greater than 30ml / min are prescribed in usual doses.

- Patients with a creatinine clearance of 10 to 30 ml / min are usually prescribed 0.5 g of amoxicillin twice a day at regular intervals.

- Patients with creatinine clearance less than 10ml / min are usually prescribed 0.5 g amoxicillin 1 time per day.

The maximum daily dose of the drug for patients with anuria is 2 g amoxicillin.

To treat bacterial infectious diseases in children, Ospamox should be used in the form of a suspension.

Ospamox - Side effects

The drug is usually well tolerated by patients, but in rare cases, the development of such side effects with the use of Ospamox:

• On the part of the gastrointestinal tract and liver: nausea, vomiting, anorexia , stool, dry mouth, flatulence, transient increase in hepatic enzyme activity. In isolated cases, there was a violation of taste sensations and staining of the tongue in a dark color.

• From the side of the peripheral and central nervous system: dizziness , headache , limb tremor, hyperkinesia. In isolated cases, mainly in patients with impaired renal function, development of seizures was noted.

• From the kidneys: interstitial nephritis.

• On the part of the hematopoiesis system: thrombocytopenia , agranulocytosis .

• Allergic reactions: skin rash, itching, hives , exanthema , erythema multiforme and maculopapular rash. In isolated cases, there was a development of Stevens-Johnson syndrome , exfoliative dermatitis, toxic epidermal necrolysis and anaphylactoid reactions, including Quincke's edema and anaphylactic shock .

In addition, the use of the drug may develop drug fever. With prolonged and / or repeated administration of the drug, it is possible to develop superinfection, fungal lesions of the mucous membranes, including oral and vaginal candidiasis.

If side effects develop, stop taking the medication and contact your doctor.

Ospamox - Contraindications

Increased individual sensitivity to the components of the drug, as well as other beta-lactam antibiotics.

The drug is not used to treat patients with infectious mononucleosis and lymphocytic leukemia .

The drug Ospamox in the form of dispersible tablets is not used to treat children under the age of 12 years.

The drug should be administered with caution to patients with dermatitis of allergic etiology, bronchial asthma , viral diseases, infectious mononucleosis, acute lymphatic leukemia and phenylketonuria .

The drug in the form of dispersible tablets should not be prescribed to patients suffering from diseases that are accompanied by vomiting and diarrhea, as in such cases absorption of amoxicillin is impaired.

Ospamox during pregnancy and lactation

The drug has no embryotoxic, mutagenic and teratogenic effects, but it penetrates well through the hematoplacental barrier and creates high concentrations of amoxicillin in the fetal tissues. The drug can be prescribed by the attending physician during pregnancy, if the expected benefit to the mother is higher than the potential risks to the fetus.

Amoxicillin is excreted into breast milk, so if you need to use the drug Ospamox DT during lactation it is recommended to resolve the issue of a possible interruption of breastfeeding.

Ospamox - Interaction with medicinal products

With the simultaneous use of the drug with allopurinol, patients may develop subcutaneous allergic reactions.

Amoxicillin in combined use increases the absorption of digoxin, therefore, when prescribing Ospamox DT, patients receiving therapy with digoxin should monitor the level of the latter in the blood and, if necessary, adjust the dose of digoxin.

The drug is not used simultaneously with disulfiram.

Amoxicillin enhances the effect of anticoagulants.

Probenecid with simultaneous application increases the plasma concentrations of amoxicillin, as well as the concentration of amoxicillin in bile. Phenylbutazone, oxyphenbutazone, indomethacin, sulfinperazone and acetylsalicylic acid in combination with the Ospamox DT drug increase the plasma concentrations of amoxicillin.

Antimicrobials that have a bacteriostatic effect significantly reduce the bactericidal action of amoxicillin.

When obtaining positive results of sensitivity tests, the drug can be used with other antimicrobials that have a bactericidal effect.

Antacids in combination with the drug Ospamox DT reduce the absorption of amoxicillin.

With the simultaneous use of the drug with oral contraceptives, there may be a decrease in the effectiveness of the latter.

Ospamox - Overdose

With the use of overestimated doses of the drug, patients may develop nausea, vomiting, diarrhea, and disturbance of the water-salt balance. With a further increase in the dose, convulsions may develop.

There is no specific antidote. In case of overdosage, gastric lavage, reception of enterosorbents and salt laxatives are indicated. In addition, with an overdose of the drug, it is necessary to carry out measures to maintain the water-salt balance.

Analogues of Ospamox

Amine, Amoxicar, Amoxylate, Amoxylate-250, Amoxicar , Amoxicillin , Amoxicillin 1000 Herds, Amoxicillin 250 Herds, Amoxicillin Watham, Amoxicillin DS, Amoxicillin-Ratiopharm, Amoxicillin-Ratiopharm 250 TC, Amoxicillin-Teva, Amoxon, Amosin , Amotide, Apo- Amoxie, Atoxylin, Gonoform, Gramox-D, Grunamox, Danemox, Cuxacillin, Ranoxil, Taisil, Uppsmox, Flemoxin Solutab, Hiconcil, E-mox.

Storage conditions and shelf life

The drug should be stored in a dry place away from direct sunlight at a temperature of 15 to 30 ° C. Shelf life - 3 years.

We want to pay special attention to the fact that the description of the drug Ospamox is presented for informational purposes only! For more accurate and detailed information about the drug Ospamox, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!