Oxacillin: instructions for use

Before buying the drug Oxacillin, you should carefully read the instructions for use, methods of application and dosage, as well as other useful information on the drug Oksatsillin. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews of patients who have already used this medication.

International name: Oxacillin (Oxacillin)

Group affiliation: semi-synthetic penicillin, antibiotic

Description of active ingredient (INN): Oxacillin

Composition and form of release

Powder for preparation of solution for intramuscular and intravenous administration: hygroscopic, white or almost white (in bottles, 1, 5, 10 or 50 bottles in a cardboard bundle);

Powder for the preparation of solution for intramuscular administration: hygroscopic, white or almost white (in vials, 1, 5 or 10 bottles in a cardboard bundle);

Tablets (10 pieces each in contour packs, 2 packs in a cardboard bundle, 20 in dark glass jars, 1 in a cardboard bundle).

In the composition of 1 bottle with powder for the preparation of solution for / m and / in the introduction of the active substance: oxacillin - 0.25, 0.5 or 1 g (in the form of sodium salt).

The composition of 1 bottle with powder for the preparation of a solution for the / m introduction includes the active substance: oxacillin - 0.25 or 0.5 g (in the form of sodium salt).

The active ingredient is included in the composition of 1 tablet: sodium oxacillin - 0.25 g.

Oxacillin - Pharmacological action

Oxacillin is a bactericidal antibiotic from the group of semi-synthetic penicillins that is resistant to the action of penicillinase. This drug blocks the synthesis of the bacterial cell wall by disrupting the late stages of peptidoglycan synthesis (prevents the formation of peptide bonds by inhibiting transpeptidase), causes the lysis of fissile bacterial cells.

Oxacillin is active against gram-positive microorganisms: Staphylococcus spp. (including those producing penicillinase), Streptococcus spp., incl. Streptococcus pneumoniae, Corynebacterium diphtheriae, Bacillus anthracis, anaerobic spore-forming rods, Gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), Actinomyces spp., Treponema spp. It is inactive with respect to the majority of gram-negative bacteria, rickettsia, viruses, protozoa, fungi. Sustainability develops slowly.

Oxacillin - Indications for use

Infectious diseases caused by gram-positive microorganisms that produce and do not produce penicillinase ( sepsis , abscess, phlegmon , cholecystitis, pyelitis , cystitis , osteomyelitis , postoperative, wound infections, infected burns, bacterial endocarditis , meningitis , sinusitis).

Application in pregnancy and lactation

The use of oxacillin in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Oxacillin - Contraindications

Hypersensitivity, incl. to other beta-lactam antibiotics.

With caution should be taken if a history of allergic reactions and / or bronchial asthma , chronic renal failure, enterocolitis on the background of antibiotics (in history), during pregnancy and lactation.

Oxacillin - Side effects

• Allergic reactions (skin itching, hives , less often angioedema, bronchospasm, in rare cases, anaphylactic shock , eosinophilia ), dyspepsia (nausea, vomiting, diarrhea);

• Pseudomembranous enterocolitis, candidiasis of the oral cavity, vaginal candidiasis ;

• Hepatotoxic effect - often develops at a dose higher than 6 g / day (hyperthermia, nausea, vomiting, icteric sclera or skin, increased activity of "liver" transaminases);

• Hematuria, proteinuria, interstitial nephritis.

With the / in the introduction - thrombophlebitis .

Oxacillin - Dosage and administration

Inside, in / in, / m. Inside, 1 hour before meals or 2-3 hours after eating. Single dose for adults and children over 6 years is 0.25-0.5 g (up to 1 g), daily - 3 g. In severe infections, the doses are increased to 6-8 g / day (daily dose divided into 4-6 receptions).

Newborn and premature babies - 0.09-0.15 g / kg / day, children under 3 months - 0.2 g / kg / day, from 3 months to 2 years - 1 g / day, from 2 to 6 years - 2 g / day. Duration of treatment - 7-10 days, with severe diseases - 2-3 weeks or more. In / m and / in: newborn and premature infants - 20-40 mg / kg / day, children under 3 months - 0.06-0.08 g / kg / day, from 3 months to 2 years - 1 g / day, from 2 to 6 years - 2 g / day, over 6 years and adults - 2-4 g / day.

When preparing solutions for intravenous injections, 0.5 ml is added to the vial from 0.25 g, and from 0.5 g - 3 ml of water for injection.

When preparing solutions intended for intravenous administration, every 0.25-0.5 g is dissolved in 5 ml of water for injection or 0.9% NaCl solution and injected slowly, for 5-10 minutes.

For the drip administration of oxacillin, the sodium salt is dissolved in 0.9% NaCl solution or in a 5% dextrose solution to a concentration of 0.5-2 mg / ml and injected for 1-2 hours at a rate of 60-100 cap / min. The duration of treatment is usually 7-10 days. In severe forms of the disease (sepsis, septic endocarditis, etc.) treatment can last 2-3 weeks or more.

Oxacillin - Special instructions

During pregnancy and lactation, they are prescribed only for "vital" indications. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

It is inappropriate to use in infections caused by microorganisms that are sensitive to benzylpenicillin.

Interaction with medicinal products

Increases the toxicity of methotrexate (competition for tubular secretion); it may be necessary to increase the doses of calcium folinate (antidote of folic acid antagonists) and its longer use.

The combination of ampicillin or benzylpenicillin with oxacillin is rational, since the latter, suppressing the activity of penicillinase, reduces thereby the destruction of ampicillin and benzylpenicillin. The spectrum of action with this combination becomes wider.

It is necessary to avoid joint use with other drugs that have a hepatotoxic effect. It is not recommended to prescribe concomitantly with bacteriostatic antibiotics (decreased efficacy). Drugs that block tubular secretion, increase the concentration of oxacillin in the blood. Antacids and laxative drugs reduce the absorption of the drug from the digestive tract.

Oxacillin analogues

There are no structural analogues to this drug, however, there are preparations containing the active ingredient oxacillin in combination with other components: Oxamp, Oxamp-sodium, Ampiox, Oxacillin sodium salt, Oksamsar.

Storage conditions and shelf life

Store in a dark place at a temperature of no higher than 25 ° C. Shelf life - 2 years.

We want to pay special attention to the fact that the description of the drug Oksatsillin is presented for informational purposes only! For more accurate and detailed information about the drug Oksatsillin, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!