Cloxacillin instructions for use

Before buying a drug Cloxacillin, you should carefully read the instructions for use, the methods of application and dosage, as well as other useful information on the drug Cloxacillin. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews of patients who have already used this medication.

Group affiliation: antibiotic, penicillin semisynthetic

Active substance (INN): Cloxacillin

Cloxacillin - Pharmacological action

Cloxacillin is an antibacterial agent from the group of semisynthetic penicillins, which acts bactericidal, blocking the synthesis of the cell wall of fissile microorganisms.

It is active against Gram-positive and Gram-negative cocci: Neisseria meningitidis and Neisseria gonorrhoeae, Corynebacterium diphtheriae, Haemophilus influenzae, Bacillus anthracis.

It is stable in acidic medium and to the action of penicillinase.

Cloxacillin - Indications for use

Infectious-inflammatory diseases caused by sensitive microorganisms:

• abscess, carbuncle , furunculosis ;

• sinusitis, otitis media, pharyngitis, tonsillitis, paratonsillar abscess;

pneumonia , pleural empyema;

• meningitis, endocarditis , sepsis , osteomyelitis ; diseases of the urinary tract;

• prevention of complications in the transplantation of the skin flap.



Cloxacillin - Side effects

Hives , itching, nausea, heartburn, diarrhea, anaphylactic shock .

Cloxacillin - Application and dosage

Adults-500 mg 4 times a day.

Children 2-10 years - 250 mg 4 times a day; up to 2 years - 125 mg 4 times a day. If necessary, the dose may be increased.

special instructions

There may be incorrect results in determining the concentration of 17-oxycorticosteroids in urine.

Interaction with medicinal products

Antacids, glucosamine, laxatives, food, aminoglycosides slow down and decrease absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including cephalosporins, cycloserine, vancomycin, rifampicin), aminoglycosides exert a synergistic effect; bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines) - antagonistic.

Increases the effectiveness of anticoagulants (suppressing the intestinal microflora, reduces the prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism which forms PABC.

Diuretics, allopurinol, tubular secretion blockers, phenylbutazone, NSAIDs reduce tubular secretion, thereby increasing the concentration.

Allopurinol increases the risk of allergic reactions (skin rashes).

Analogues of Cloxacillin

Amoxiclav, Augmentin, Ospamox, Medoclav, Ampicillin, Unazine, Bicillin-5, Retarpen, Benzylpenicillin, Bicillin-3, Timentine, Gramox, Penamecillin, Amosin, Amoxiclav quiquate, Ampiox, Carbenicillin disodium salt, Piperacillin, Trifamox iblock, Amoxyl, Ampicillin sodium Salt, Ampicillin Trihydrate, Flemoclav Soluteba, Carfecillin, Procaine-Benzylpenicillin, Amoxiclav (Tablets), Ampicillin for Injection, Bacampicillin, Flemoxin Soluteba, Clonacom-r, Sultamycillin, Ampicillin Tablets, Benzathine Benzylpenicillin, Clonacom, Amoxicill N, tazocin, smallpox 750 Benzylpenicillin potassium salt, procaine benzylpenicillin, mezlocillin, Phenoxymethylpenicillin, Benzylpenicillin novocaine salt Ampisid, oxacillin sodium, flucloxacillin, Ospamoks dt, Bitsillin-1, smallpox, Amoksiklav 2x, azlocillin.

Storage conditions and shelf life

Protect from excessive heating. Keep out of the reach of children.

The prepared solution can be stored for 24 hours (in a refrigerator - 72 hours).

We want to pay special attention to the fact that the description of the drug Cloxacillin is presented for informational purposes only! For more precise and detailed information about the drug Kloxacillin, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!