Application instructions for use

We ask you to pay your attention that before buying the drug Isfipro it is necessary to carefully read the instructions for use, the methods of application and dosage, as well as other useful information on the preparation of Isfipro. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews of patients who have already used this medication.

Ифиципро - Composition and form of release

Active ingredient: Ciprofloxacin (Ciprofloxacin)

1 coated tablet contains ciprofloxacin 250 or 500 mg (as hydrochloride); in a contour acheikova packing 10 pcs., in a box of 10 packages.

100 ml solution for injection - 200 mg (in the form of lactate); in a sterile disposable plastic bottle 100 ml, in a box 1 bottle.

Ифиципро - Indications for use

Infections and inflammatory diseases caused by microorganisms sensitive to ciprofloxacin:

- respiratory tract;

- Ear, throat of inosuction: otitis media, sinusitis, frontal sinitis, mastoiditis, tonsillitis, pharyngitis;

- kidney and urinary tract: cystitis , pyelonephritis;

- genitals: prostatitis , adnexitis , salpingitis , oophoritis , endometritis , tubular abscess, pelvioperitonitis , gonorrhea , chancroid , chlamydia ;

- digestive system (including mouth, teeth, jaws), gallbladder and bile ducts: salmonellosis , typhoid fever , intraperitoneal abscesses, campylobacteriosis , iersiniosis , shigellosis, cholera ;

- skin, mucous membranes and soft tissues: wounds, burns, infected ulcers, abscesses, phlegmon ;

- Musculoskeletal system: osteomyelitis , septic arthritis.

Prevention of infections during surgical interventions.

Ciprofloxacin is indicated for the treatment of sepsis and peritonitis, as well as for the prevention and treatment of infections in patients with reduced immunity (with immunosuppressant therapy).

Ифиципро - the Pharmacological action

Isfipro is a broad-spectrum antimicrobial agent, a derivative of fluoroquinolone, suppresses bacterial DNA gyrase (topoisomerases II and IV, responsible for the process of supercoiling the chromosomal DNA around the nuclear RNA, which is necessary for reading the genetic information), disrupts DNA synthesis, growth and division of bacteria; causes significant morphological changes (including the cell wall and membranes) and the rapid death of the bacterial cell.

Ifipro acts bactericidally on gram-negative organisms during rest and division (since it affects not only the DNA-gyre, but also causes lysis of the cell wall), Gram-positive microorganisms only during the fission period. Low toxicity for macroorganism cells is explained by the absence of DNA-gyrase in them.

Against the background of taking ciprofloxacin, there is no parallel development of resistance to other actitobiotics that do not belong to the group of inhibitors of gyrase, which makes it highly effective against bacteria that are resistant, for example to aminoglycosides, penicillins, cephalosporins, tetracyclines and many other antibiotics.

Gram-negative aerobic bacteria are sensitive to ciprofloxacin: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp. , Morganella morganii, Vibrio spp., Yersinia spp.), Other gram-negative bacteria (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), Some intracellular pathogens - Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Corynebacterium diphtheriae; Gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).

The majority of staphylococci, resistant to methicillin, are resistant to ciprofloxacin. The sensitivity of Streptococcus pneumoniae, Enterococcus faecalis, Mycobacterium avium (located intracellularly) is moderate (their suppression requires high concentrations). The drug is resistant: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Not effective against Treponema pallidum. Resistance develops very slowly, since on the one hand, after the action of ciprofloxacin, there are practically no persistent microorganisms, and on the other hand bacterial cells do not have enzymes that inactivate it.

Ифиципро - Contraindications

Hypersensitivity, children's age (up to 18 years - until the completion of the formation of the skeleton), pregnancy , lactation.

C Caution: Severe atherosclerosis of cerebral vessels, cerebral circulation disorder, mental illness, epilepsy, epileptic syndrome, severe renal and / or hepatic insufficiency , elderly age.

Ифиципро - Side effects

• On the part of the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, decreased appetite, cholestatic jaundice (especially in patients with liver disease), hepatitis, hepatonecrosis.

• On the part of the nervous system: dizziness , headache , fatigue, anxiety, tremor, insomnia, nightmarish dreams, peripheral paralysis (anomaly of perception of pain), increased sweating, increased intracranial pressure, confusion, depression , hallucinations, and other manifestations of psychotic reactions (occasionally progressing to conditions in which the patient can do harm to himself), migraine, fainting, thrombosis of the cerebral arteries.

• On the part of the senses: a violation of taste and smell, visual impairment (diplopia, change in color perception), tinnitus, hearing loss.

• On the part of the CAS: tachycardia , heart rhythm disturbances, lowering blood pressure.

• From the hematopoietic system: leukopenia , granulocytopenia, anemia , thrombocytopenia , leukocytosis , thrombocytosis , hemolytic anemia .

• On the part of laboratory indicators: hypoprothrombinemia, increased activity of "hepatic" transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia , hyperglycemia .

• On the part of the urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, decreased renal nitrogen function, interstitial nephritis.

• Allergic reactions: skin itching , urticaria , the formation of blisters accompanied by bleeding, and the appearance of small nodules that form scabs, drug fever, pinpoint hemorrhages on the skin ( petechiae ), swelling of the face or larynx, dyspnea, eosinophilia , increased photosensitivity, vasculitis , nodal erythema , multiforme exudative erythema (including Stevens-Johnson syndrome ), toxic epidermal necrolysis ( Lyell's syndrome ).

Other: arthralgia, arthritis, tendovaginitis , tendon ruptures, asthenia, myalgia, superinfections (candidiasis, pseudomembranous colitis), "tides" of blood to the face.

Overdose of the drug

Treatment: a specific antidote is unknown. It is necessary to carefully monitor the patient's condition, perform gastric lavage and other emergency measures, ensure sufficient fluid intake.

With the help of hemo- or peritoneal dialysis, only a small (less than 10%) amount of the drug can be excreted.

Ифиципро - Method of administration and dose

Inside, to 0.25 g 2-3 times a day, with severe infections - 0.5-0.75 g 2-3 times a day.

With infections of the urinary tract - 0.25-0.5 g 2 times a day; course of treatment - 7-10 days.

With uncomplicated gonorrhea - 0.25-0.5 g once; when combined gonococcal infection with Chlamydia and Mycoplasma - 0.75 g every 12 hours for 7-10 days.

With chancroid, 0.5 g 2 times a day for several days.

When meningococcal carriage in the nasopharynx - once, 0.5 or 0.75 g.

With chronic carrier of salmonella - inside, 0.25 g 4 times; course of treatment - up to 4 weeks. If necessary, the dosage can be increased to 0.5 g 3 times a day.

With pneumonia , osteomyelitis - inside, at 0.75 g 2 times a day. The duration of treatment of osteomyelitis can be up to 2 months.

For gastrointestinal infections caused by Staphylococcus aureus, 0.75 g every 12 hours for 7-28 days. Treatment should continue for at least 3 days after the normalization of body temperature or the disappearance of clinical symptoms. At the glomerular filtration rate (CK 31-60 ml / min / 1.73 m2 or serum creatinine concentration from 1.4 to 1.9 mg / 100 ml), the maximum daily dose is 1 g. At a glomerular filtration rate below 30 ml / min / 1.73 square meters. m or serum creatinine concentration above 2 mg / 100 ml maximum daily dose - 0.5 g. If the patient undergoes hemodialysis or peritoneal dialysis - 0.25-0.5 g / day, but the drug should be taken after a hemodialysis session.

In severe infections (for example, in recurrent cystic fibrosis , infections of the abdominal cavity, bones and joints) caused by Pseudomonas or staphylococci, in acute pneumonia caused by Streptococcus pneumoniae and in chlamydial infections of the urogenital tract, the dose should be increased to 0.75 g every 12 hours. Tablets should be swallowed whole with a small amount of liquid after ingestion. When taking a tablet on an empty stomach, the active substance is absorbed more quickly. IV infusion: the duration of infusion is 30 minutes at a dose of 0.2 g and 60 minutes at a dose of 0.4 g. Infusion solutions ready for use can be combined with 0.9% NaCl solution, Ringer's and Ringer's lactate solution, 5 and 10% solution dextrose, 10% fructose solution, and also a solution containing 5% dextrose solution with 0.225-0.45% NaCl solution.

In uncomplicated urinary tract infections, infections of the lower respiratory tract, a single dose of 0.2 g; with complicated infections of the upper sections of the urinary tract, in severe infections (including pneumonia, osteomyelitis), a single dose of 0.4 g. If necessary, in / in the treatment of especially serious, life-threatening or recurrent infections caused by Pseudomonas, Staphylococcus or Streptococcus pneumoniae, the dose can be increased to 0.4 g with a frequency of up to 3 times a day. The duration of treatment for osteomyelitis can reach up to 2 months.

With chronic carrier of salmonella - 0.2 g 2 times a day; course of treatment - up to 4 weeks. If necessary, the dosage can be increased to 0.5 g 3 times a day.

In acute gonorrhea - 0.1 g once. To prevent infections during surgical interventions - 0.2-0.4 g for 0.5-1 h before surgery; When the duration of the operation is more than 4 hours, re-enter in the same dose. Average duration of treatment: 1 day - with acute uncomplicated gonorrhea and cystitis; up to 7 days - with infections of the kidneys, urinary tract and abdominal cavity, during the entire neutropenic phase - in patients with weakened body defenses, but no more than 2 months - with osteomyelitis and 7-14 days - with all other infections.

With streptococcal infections due to the danger of late complications, as well as with chlamydial infections, treatment should last at least 10 days. In patients with immunodeficiency treatment is carried out throughout the neutropenia period. Treatment should be conducted for at least 3 days after the normalization of body temperature or the disappearance of clinical symptoms. At the glomerular filtration rate (CK 31-60 ml / min / 1.73 m2 or serum creatinine concentration from 1.4 to 1.9 mg / 100 ml) the maximum daily dose is 0.8 g. At the glomerular filtration rate (CC below 30 ml / min / 1.73 m2 or a serum creatinine concentration above 2 mg / 100 ml), the maximum daily dose is 0.4 g. Elderly patients are reduced by 30%.

In peritonitis, it is permissible to use intraperitoneal administration of infusion solutions at a dose of 50 mg 4 times per day per liter of dialysate. After IV application, you can continue treatment orally.

Ифиципро - Special instructions

With the simultaneous administration of ciprofloxacin and drugs for general anesthesia from the barbituric acid derivative group, continuous monitoring of heart rate, blood pressure, and ECG is necessary.

To avoid the development of crystalluria, exceeding the recommended daily dose is inadmissible, adequate fluid intake and maintenance of acid urine reaction are also necessary.

During treatment, one should refrain from engaging in potentially dangerous activities that require increased attention and speed of mental and motor reactions. Patients with epilepsy, seizures in the anamnesis, vascular diseases and organic brain lesions, in connection with the threat of the development of adverse reactions from the central nervous system, ciprofloxacin should be prescribed only for "vital" indications.

If a severe and prolonged diarrhea occurs during or after treatment, the diagnosis of pseudomembranous colitis should be ruled out, which requires immediate discontinuation of the drug and the appropriate treatment. When pain occurs in the tendons or the first signs of tendovaginitis treatment should be discontinued (individual cases of inflammation and even rupture of tendons during treatment with fluoroquinolones are described).

During the treatment period, avoid direct sunlight.

Ифиципро - Interaction with medical products

Due to a decrease in the activity of microsomal oxidation in hepatocytes, it increases the concentration and prolongs T1 / 2 theophylline (and other xanthines, for example caffeine), oral hypoglycemic drugs, indirect anticoagulants, and helps to reduce the prothrombin index.

When combined with other antimicrobial drugs (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergy is usually observed; can be successfully used in combination with azlocillin and ceftazidime in infections caused by Pseudomonas spp .; with mezlocillin, azlocillin, etc. beta-lactam antibiotics - with streptococcal infections; with isoxazole penicillins and vancomycin - with staphylococcal infections; with metronidazole and clindamycin - with anaerobic infections. Increases the nephrotoxic effect of cyclosporine, there is an increase in serum creatinine, in such patients monitoring of this indicator is required 2 times a week. With simultaneous reception increases the effect of indirect anticoagulants.

Oral administration together with Fe-containing drugs, sucralfate and antacid medicines containing Mg2 +, Ca2 + and Al3 +, leads to a decrease in absorption of ciprofloxacin, therefore, it should be prescribed 1-2 hours before or 4 hours after the administration of the above drugs. NSAIDs (excluding ASA) increase the risk of seizures.

Didanosine reduces the absorption of ciprofloxacin due to the formation with it of complexes with didanosine-containing Al3 + and Mg2 +. Metoclopramide accelerates absorption, which leads to a decrease in the time to reach its Cmax. Co-administration of uricosuric drugs leads to a delay in excretion (up to 50%) and an increase in the plasma concentration of ciprofloxacin.

The infusion solution is pharmaceutically incompatible with all infusion solutions and drugs that are physically and chemically unstable under acidic conditions (the pH of the infusion solution of ciprofloxacin is 3.9-4.5). Do not mix the IV solution with solutions having a pH of more than 7.

Analogues of Isipro

Aquacycra, Alzipro , Arflox, Afenoxin, Betaziprol, Vero-Ciprofloxacin, Zindolin, Isfipro OD, Quintor, Quipro, Laiproquin, Liprochin, Medocyprin, Microflox, Neofloxin, Proxacin, Procipro, Recipro, Siflox, Tatsip, Tseprova, Cefobak, Ciloxane, Ziplex , Cipranol, Cyprus, Cyprinol, Ciprinol SR, Ciprobay, Ciprobin, Ciprobrin, Ciprova, Ciprovin 250, Ciprodar, Ciprodox, Ciproquin, Ciproxine, Ciprolacer, Ciprolet, Ciprolon, Ciprolet, Cipronate, Cipropan, Ciprosan, Ciprosin, Ciprosol, Ciprofloxabol, Ciprofloxacin , Ciprofloxacin Buffus, Ciprofloxacin-A COS, Ciprofloxacin-Ferein, Ciprofloxacin-FPO, Ciprofloxacin hydrochloride, Ciprozinal, Cytar, Cyflosin, Cyfloxin, Cyflosin, Cyflocin, Cyphran, Cyphran OD

Storage conditions

In the dark place at a temperature of no higher than 30 ° C.

We want to pay special attention to the fact that the description of the medicinal preparation Isfipro is presented for informational purposes only! For more accurate and detailed information about the medicinal preparation of Isfipro, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!