Donovanosis (inguinal granuloma, venereal granuloma) is a classical, slowly progressing chronic venereal disease. Donovanosis occurs at any age, but more often they are sick people of both sexes aged 20 to 40 years (ratio of patients men to sick women - 6: 1). The disease is most widespread in tropical countries, especially in South Africa, South India, Papua New Guinea, in some areas of Brazil and Australia. In Europe, donovanosis is extremely rare and is an "imported" disease. The factors contributing to the spread of this infection include high ambient temperature and a humid climate.
In most cases, infection with donovanosis occurs sexually (very rarely in the home). Due to the fact that this disease is slightly contagious, the risk of infection during sexual intercourse with a sick person is from 1 to 50%
The incubation period of donovanosis is from one to twelve weeks. At the initial stage of the disease, a papule (a small nodule of red color) is formed on the skin of the genital organs, which after two days becomes ulcerated, forming on this place a painless fleshy red ulcer with a velvety surface. The ulcer has uneven raised edges and a tendency to bleed slightly. As the disease progresses, the ulcer gradually increases in size, seizing all large areas of skin. An increase in regional lymph nodes is not observed. In some cases, formation of pseudobubbles (subcutaneous nodules, which are formed as a result of proliferation of granulation tissue and localized in the inguinal region) can be observed. поражаются половые органы и кожа вокруг заднего прохода, однако иногда может встречаться поражение полости рта, шеи, лица и других областей. Most often with this venereal disease, the genital organs and skin around the anus are affected, but sometimes the oral cavity, neck, face and other areas can be affected. Possible complications of donovanosis: narrowing of the anus, narrowing of the vagina, narrowing of the urethra, elephantia of the genital organs
Treatment of this disease consists in the intake of antibiotics and sulfanilamide preparations. The most effective drugs are: erythromycin, tetracycline, sulfamethoxazole, trimethoprim, gentamicin, chloramphenicol, triamphenicol, ceftriaxone and azithromycin. The duration of treatment of donovanosis is from three weeks to three months.