Disease of Itenko-Cushing

Болезнь Иценко-Кушинга Disease of Itenko-Cushing is a severe, chronic disease of the brain, which is caused by the defeat of the hypothalamic-pituitary region. This disease can develop after traumatic brain injuries, neuroinfections, due to tumors of the pituitary gland


- The face becomes "moon-shaped"

- There is an increased deposition of fat in the areas of: abdomen, shoulder girdle, neck and face

- As a result of muscular dystrophy, limb thinning occurs

- Increased blood pressure (hypertension)

- Decreased bone density (osteoporosis)

- Sugar in the blood rises (hyperglycemia)

- Muscular weakness appears

- There is a distinct venous pattern on the limbs and chest

- In women, possible manifestations of hairy style for men

A person with Ithenko-Cushing's disease gradually acquires a rather specific appearance - a moon-shaped red face, a fat body with thin limbs. On the abdomen, due to obesity, stretch marks appear. Places of friction (elbows and neck) and skin folds due to increased pigmentation become darker than the rest of the skin. The disease significantly reduces immunity, so that about 50% of patients die from infectious diseases. Against the backdrop of the Itenko-Cushing disease, serious psychic abnormalities often develop.

There are three forms of the disease: mild, moderate and severe.

The course of the disease can be progressive (the symptomatology develops over a period of six to twelve months) and torpid (the gradual increase in symptoms for three to ten years)


Until recently, X-ray irradiation of the interstitial-pituitary region was the only treatment for this disease. Now in the arsenal of the doctor there are more modern and progressive means and methods of treatment that can be divided into two groups:

- Methods based on local suppression of hyperfunction of the adrenal cortex

- Methods aimed at eliminating the focus in the hypothalamic-pituitary region

However, even in spite of the fact that in our time the treatment has become much more effective - the quality therapy of the Itenko-Cushing's disease in children has not yet been fully developed.


This type of treatment is based on the use of drugs that suppress the secretion of hormones of the adrenal cortex (mammoth, chloride). Depending on the severity of these or other symptoms additionally prescribed antidiabetic, anabolic and antihypertensive agents


This type of treatment is divided into two types: adrenomectomy and transsphenoidal adenomectomy.

Adrenomectomy is used as an additional method of treatment for radiation therapy and consists in the removal of one (or both) of the adrenal gland.

Transsphenoidal adenomectomy consists in the removal of the pituitary tumor. In the case of a successfully performed operation, the first effect manifests itself within ten days and is expressed in a decrease in the main symptoms of hypercorticism, a decrease in appetite and overall improvement in well-being.

Radiation therapy

By means of radioadenomectomy (proton beam), pituitary activity is suppressed. The effectiveness of radiotherapy is manifested in 6-12 months and is caused (in the majority of patients) by the complete normalization of clinical and hormonal parameters.

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