Amosin: instructions for use

We ask you to pay your attention that before buying Amosin product it is necessary to carefully read the instructions for use, the methods of application and dosage, as well as other useful information on the Amosin preparation. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for proper use, recommended dosage, contraindications, as well as reviews of patients who have already used this medication.

Amosin - Composition and form of release

• 1 capsule of Amosin contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 250 mg;
Additional Ingredients.

• 1 sachet for preparation of Amosin 125 oral suspension contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 125 mg;
Additional Ingredients.

• 1 sachet for preparation of oral suspension Amosin 250 contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 250 mg;
Additional Ingredients.

• 1 packet for the preparation of Amosin 500 oral suspension contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 500 mg;
Additional Ingredients.

• 5 ml of the finished Amosin suspension contain:
Amoxicillin trihydrate (in terms of amoxicillin ) - 250 mg;
Additional Ingredients.

• 1 tablet of Amosin 250 contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 250 mg;
Additional Ingredients.

• 1 tablet of Amosin 500 contains:
Amoxicillin trihydrate (in terms of amoxicillin) - 500 mg;
Additional Ingredients.

• Amosin capsules gelatin, white, №0; the contents of the capsules are white granules.
1 capsule contains amoxicillin (in the form of trihydrate) 250 mg;
auxiliary substances: potato starch;
gelatin capsule composition: titanium dioxide, methylhydroxybenzoate, propylhydroxybenzoate, acetic acid, gelatin.
20 pcs. packaged.

• Amosin tablets white or almost white, flat-cylindrical, with a facet and a risk.
1 tablet contains amoxicillin (in the form of trihydrate) 250 or 500 mg;
auxiliary substances: potato starch, magnesium stearate, calcium stearate, magnesium hydrosilicate (talc), povidone (kollidon 90F).
10 pieces. packaged

• Amosin powder for the preparation of a suspension for ingestion of white with a yellowish tint of color, with a specific odor; a prepared suspension of white with a yellowish tint of color, with a specific odor.
1 packet contains amoxicillin (in the form of trihydrate) 125 mg / 250 mg / 500 mg.
auxiliary substances: polyvinylpyrrolidone (povidone), dextrose, disodium salt of ethylenediaminetetraacetic acid (trilon B) (disodium edetate), sodium phosphate disodium (sodium hydrogen phosphate), sodium α-glutamate monohydrate, food flavoring, vanillin, sucrose.
10 packets of 1.5 g / 3 g / 6 g.

Amosin - Indications for use

Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:

- infections of the respiratory system (including bronchitis, pneumonia );

- infections of the ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);

- infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis , urethritis, gonorrhea );

- gynecological infections (including endometritis , cervicitis );

- Gastrointestinal tract infections (including peritonitis, enterocolitis, typhoid fever , cholangitis, cholecystitis);

- skin and soft tissue infections (including erysipelas , impetigo , secondarily infected dermatoses);

- Leptospirosis ;

- listeriosis ;

- Lyme disease (borreliosis);

- dysentery;

- salmonellosis , salmonella;

- meningitis;

- endocarditis (prophylaxis);

- septicemia

Amosin - Pharmacological action

Amosin is an active bactericidal antibiotic of a broad spectrum of action of a group of semisynthetic penicillins that inhibits transpeptidase, which breaks the synthesis of peptidoglycan (supporting cell wall polymer) during fission and growth, causing bacterial lysis. Acid-resistant.

It is active against aerobic gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp .; aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori, Klebsiella spp.

The microorganisms producing penicillinase are resistant to the action of amoxicillin. The action develops 15-30 minutes after administration and lasts 8 hours

Amosin - Dosage and administration

Amosin is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years of age (with a body weight> 40 kg) are prescribed 500 mg 3 times a day, in severe cases - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, at the age of 2 to 5 years - 125 mg 3 times a day, at the age of 2 years - 20 mg / kg / day in 3 divided doses. The course of treatment is 5-12 days. Children under the age of 5 years, the drug is administered in the form of a suspension.

For the treatment of acute uncomplicated gonorrhea, Amosin is prescribed in a dose of 3 g once; in the treatment of women, repeated intake of this dose is recommended.

In acute infectious diseases of the digestive tract (paratyphoid, typhoid) and biliary tract, with gynecological infectious diseases adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

With salmonella carrying adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in small surgical interventions, adults are prescribed a dose of 3-4 g for 1 h before the procedure. If necessary, a repeat dose is administered after 8-9 hours. In children, the dose is reduced by half.

In patients with impaired renal function (QC 15 to 40 ml / min), the interval between doses is increased to 12 hours, in the terminal stage of chronic renal failure (CC <10 ml / min) Amosin dose should be reduced by 15-50% or increase the interval between doses up to 24 hours, with anuria - the maximum dose is 2 g per day.

Rules for the preparation of suspension

In a clean glass poured boiled chilled water in the required amount, then pour the contents of one packet and mix until a homogeneous suspension is obtained.

• Dose 125 mg - 2.5 ml of water;

• Dose 250 mg - 5 ml of water;

• 500 mg dose - 10 ml of water.

After taking the glass, rinse with water, dry and store in a dry, clean place.

Amosin - Side effect

• Allergic reactions: possibly - hives , skin hyperemia, erythema , angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia , exfoliative dermatitis, erythema multiforme exudative , Stevens-Johnson syndrome , reactions similar to serum sickness; in isolated cases - anaphylactic shock .

• On the part of the digestive system: dysbacteriosis, taste change, vomiting, nausea, diarrhea, stomatitis, glossitis, impaired liver function, moderate increase in hepatic transaminase activity; rarely - pseudomembranous enterocolitis.

• From the central nervous system and peripheral nervous system: agitation, anxiety, insomnia, ataxia , confusion, behavior change, depression , peripheral neuropathy, headache, dizziness , convulsive reactions.

• From the urinary system: rarely - interstitial nephritis.

• On the part of the hematopoiesis system: leukopenia , neutropenia , thrombocytopenic purpura , anemia .

• Other: shortness of breath, tachycardia , vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced resistance of the body).

Amosin - Contraindications

- allergic diathesis ;

- bronchial asthma , pollinosis ;

- infectious mononucleosis ;

- lymphocytic leukemia ;

- liver failure ;

- Gastrointestinal disease in history (especially colitis, associated with the use of antibiotics);

- lactation period (breastfeeding);

- hypersensitivity to the components of the drug;

- hypersensitivity to other penicillins, cephalosporins, carbapenems;

- Children under 3 years old (for tablets and capsules).

Caution should be given to Amosin in pregnancy, kidney failure, and also in case of a history of bleeding.

special instructions

During the course of treatment with Amosin, it is necessary to monitor the status of the functions of the blood, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

In the treatment of patients with bacteremia, the bacteriolysis reaction rarely develops (the Yarisch-Gerxheimer reaction).

In patients who are hypersensitive to penicillins, there may be cross-allergic reactions with cephalosporin antibiotics.

In the treatment of mild diarrhea, Amosin should avoid prescribing antidiarrheal drugs that reduce intestinal peristalsis; it is possible to use kaolin- or attapulgite-containing antidiarrhoeic agents. In severe diarrhea it is necessary to conduct differential diagnosis and prescribe appropriate therapy.

Treatment should continue for another 48-72 hours after the disappearance of clinical signs of the disease.

With simultaneous use of estrogen-containing oral contraceptives and amoxicillin, additional methods of contraception should be used, if possible.

Analogues of Amosin

The drug Amosin has many analogues. Below we present some of them: Amoxicar; Amine; Amoxylate; Amoxicillin; Amoxon; Atoxylin; Gonoform; Ospamox; Taisil; Flemoxin solute; E-mox.

Storage conditions and shelf life

Keep out of the reach of children, dry, protected from light. Powder for the preparation of the suspension should be stored at a temperature of no higher than 25 ° C.

We want to pay special attention to the fact that the description of the Amosin medication is provided for informational purposes only! For more accurate and detailed information about the Amosin medication, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!