Allertec: instructions for use

We ask you to pay your attention that before buying the drug Allertec, you must carefully read the instructions for use, methods of application and dosage, as well as other useful information on the drug Allertec. On the site "Encyclopaedia of Diseases" you will find all the necessary information: instructions for use, dosage, contraindications, as well as reviews of patients who have already used this medication.

Allertec - Composition and form of release

International Nonproprietary Name: cetirizine

Dosage form: coated tablets.

Tablets of 10 mg, coated: 7, 10 or 20 pieces in blisters, enclosed in a cardboard box with instructions for use.

The active substance cetirizine dihydrochloride 10 mg.

Excipients: lactose, microcrystalline cellulose, corn starch, polyvinylpyrrolidone 25, magnesium stearate, hydroxypropyl methylcellulose, sodium starch gluconate, silica gel, sodium lauryl sulfate, polyethylene glycol 6000.

Tablets are oblong with a one-sided separating risk, coated with a coat from white to cream color.

Pharmacotherapeutic group: antiallergic agent - H1-histamine receptor blocker.

Allertec - Pharmacological properties

Pharmacodynamics

The drug Allertec is an effective antihistamine, antiallergic agent. The active substance cetirizine, belongs to the group of competitive antagonists of histamine, blocks H1-histamine receptors, has almost no anticholinergic and antiserotonin action.

Allertec prevents development and facilitates the course of allergic reactions, has anti-allergic, antipruritic, anti-exsudative action. Cetirizine influences the "early", histamine-dependent stage of allergic reactions, reduces migration of inflammatory cells, inhibits the release of mediators participating in a late allergic reaction. Reduces the permeability of capillaries, prevents the development of edema of tissues, relieves spasm of smooth muscles. In therapeutic doses, it practically does not have a sedative effect. Against the background of the course, tolerance does not develop. The drug begins in 20 minutes (in 50% of patients), after 1 hour (95% of patients), and persists for 24 hours.

Pharmacokinetics

Suction: after intake of cetirizine quickly and well absorbed from the gastrointestinal tract. The maximum level of concentration is determined after about 30-60 minutes.

Eating does not have a significant effect on the amount of absorption, but in this case, the rate of absorption is slightly reduced.

Distribution: cetirizine binds to plasma proteins approximately 93%. The volume of distribution (Vd) is low (0.5 l / kg), the preparation does not penetrate into the cell.

The drug does not penetrate the blood-brain barrier.

Metabolism: cetirizine is poorly metabolized in the liver with the formation of an inactive metabolite. At 10-day application in a dose of 10 mg accumulation of the drug is not observed.

Excretion: approximately 70% of the kidneys are mostly unchanged.

After a single dose of a single dose, the half-life period is about 10 hours. In children aged 2 to 12 years, the half-life is reduced to 5-6 hours.

If the renal function is impaired (creatinine clearance is less than 11-31 ml / min) and hemodialysis patients (creatinine clearance less than 7 ml / min), the half-life period increases by 3 times, the clearance decreases by 70%.

Against the backdrop of chronic diseases, as well as in elderly patients there is an increase in the half-life of 50% and a decrease in clearance by 40%.

Allertec - Indications for use

- seasonal and year-round allergic rhinitis ;

- allergic conjunctivitis ;

- Pollinosis (hay fever);

- urticaria , incl. chronic idiopathic;

- itching allergic dermatoses (including atopic dermatitis, neurodermatitis );

- Quincke's edema .

Allertec - contraindications

Hypersensitivity to any of the components of the drug.

Children under 6 years. Pregnancy, lactation.

With caution should be taken in chronic renal failure of moderate to severe severity (requires a correction of the dosing regimen), as well as elderly patients (possibly reducing glomerular filtration).

Allertec instructions for use and dosage

Inside, regardless of the meal, without chewing and washing down with a small amount of water, preferably in the evening.

Adults and children over the age of 12 years - 1 tablet (10 mg), 1 time per day.

Children aged 6 to 12 years - 1 tablet (10 mg) - 1 time per day or 1/2 tablet (5 mg) 2 times a day.

In renal failure, the recommended dose should be reduced by a factor of 2.

If the liver function is impaired, it is necessary to select the dose individually, especially with simultaneous renal failure.

Elderly patients with normal renal function are not required to adjust the dose.

Allertec - side effect

Usually the drug Allertec is well tolerated. In some cases, side effects are possible in the form of headache, drowsiness, dizziness, irritation, dry mouth, abnormalities from the digestive tract in the form of dyspepsia, abdominal pain, flatulence.

In rare cases, there may be signs of hypersensitivity to the drug in the form of hives, swelling, dyspnea. In this case, the drug should be discontinued immediately and consult a doctor immediately.

Allertec - Overdose

Symptoms: taking the drug once in a dose of more than 5 tablets may be accompanied by signs of intoxication in the form of drowsiness, in children, an overdose of the drug may be accompanied by anxiety and increased irritability, possibly signs of anticholinergic action in the form of urine retention, dry mouth, constipation.

Treatment: induce vomiting, rinse the stomach, take activated charcoal, immediately consult a doctor. There is no specific antidote. Hemodialysis is ineffective.

Interaction with other drugs

It is not recommended without consulting a doctor to combine the use of Allertec with other medicines.

With simultaneous administration with bronchodilators, containing theophylline as an active substance, it is possible to increase the frequency of side effects of Allertec.

special instructions

Care should be taken when prescribing the drug to persons who perform activities requiring high speed of mental and physical reactions, making quick decisions (for example, driving vehicles, servicing cars, working at height, etc.).

Data on the interaction of cetirizine with alcohol have not been obtained to date, despite this, the use of alcoholic beverages in the treatment with this drug is not recommended.

Allertec is contraindicated in pregnancy ! If it is necessary to use the drug during lactation, the question of stopping breastfeeding should be resolved.

Analogues of Allertec

Alerza, Aneralgine, Zetrinal, Zincet, Zirtek, Zodak, Letizen, Parlazin, Cetirizin, Cetirizin Hexal, Cetirizin DS, Cetirinax, Cetrin.

Shelf life and storage conditions

4 years. Do not use after the expiration date printed on the package.

Store in a dry place, protected from light, out of reach of children, at a temperature of 15-25 ° C.

Terms of leave from pharmacies: Without a prescription.

We want to pay special attention to the fact that the description of the drug Allertec is presented for informational purposes only! For more accurate and detailed information about the drug Allertec, please refer exclusively to the manufacturer's annotation! Do not self-medicate! You should definitely consult a doctor before starting the drug!